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Micafungin sodium

Catalog No. T1794Cas No. 208538-73-2
Alias Mycamine Sodium, FK463 Sodium, FK 463

Micafungin sodium (FK 463) is the sodium salt form of micafungin, a semi-synthetic echinocandin derived from a natural product of the fungus Coleophoma empetri with antifungal activity.

Micafungin sodium

Micafungin sodium

Purity: 100%
Catalog No. T1794Alias Mycamine Sodium, FK463 Sodium, FK 463Cas No. 208538-73-2
Micafungin sodium (FK 463) is the sodium salt form of micafungin, a semi-synthetic echinocandin derived from a natural product of the fungus Coleophoma empetri with antifungal activity.
Pack SizePriceAvailabilityQuantity
2 mg$39In Stock
5 mg$63In Stock
10 mg$107In Stock
25 mg$216In Stock
50 mg$347In Stock
100 mg$553In Stock
500 mg$1,220In Stock
1 mL x 10 mM (in DMSO)$153In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
Micafungin sodium (FK 463) is the sodium salt form of micafungin, a semi-synthetic echinocandin derived from a natural product of the fungus Coleophoma empetri with antifungal activity.
In vitro
Micafungin (10 mg/mL) effectively inhibits biofilm formation in the majority of examined isolates and significantly reduces mRNA transcription levels across all tested genes compared to untreated samples[1]. Additionally, when combined with KB425796-C, micafungin exhibits a fungicidal effect, significantly diminishing the colony-forming unit (CFU) count, unlike the fungistatic outcome (no CFU reduction) observed when either drug is applied independently[2].
In vivo
Micafungin administration at a dose of 1 mg/kg notably extends survival in mice compared to those receiving saline. Additionally, a regimen combining micafungin (0.1 mg/kg) with KB425796-C (32 mg/kg) appears to enhance survival duration when compared to treatment with only micafungin (0.1 mg/kg). Treatment with micafungin alone reduces colony-forming units (CFUs) in the liver, though its clearance efficacy is not as pronounced as in the kidney. Significantly, a combined treatment of micafungin and KB425796-C markedly lowers CFU counts across all tested doses compared to micafungin treatment alone, demonstrating a superior clearance effect than that seen with AMPH-treated animals[2].
Kinase Assay
HEK-GPR119 cells are transfected with GloSensor 22F plasmid and used for dynamic cAMP measurements 24-30 h later. Cell suspensions are made by dislodging the cells using PBS wash and Accutase treatment followed by resuspension in culture media. Cells are then washed twice by pelleting through centrifugation (300 g, 5 min) and resuspension in assay buffer (Hank's Balanced Salt Solution supplemented with 20 mM HEPES and 0.01% fatty acid free BSA, pH 7.4). Cells are then counted and diluted to 600,000 cells/mL in buffer, before GloSensor cAMP reagent is added (2% v/v) and equilibrated with the cells for 2 h at 20°C with periodic mixing. 50 μl/well of cells are added to white-bottomed 384 well plates (30,000 cells/well) in triplicate and baseline luminescence is measuring using an Envision plate-reader. 5 μL of MBX-2982 (serially diluted in DMSO and then diluted 1:100 in assay buffer to obtain ×10 concentrated solution) is manually added to the assay wells to achieve the stated final concentration. Plates are incubated at 20°C with luminescence read at regular intervals to detect dynamic cAMP changes over time within the same wells. cAMP responses at each time-point are expressed as fold over control (vehicle-treated cells)[1].
Cell Research
Each fungal isolate is incubated statically in yeast-maltose (YM) agar broth for 24?h at 30°C.?Cryptococcus neoformans?YC203 is grown in YM broth medium for 20?h at 30°C with shaking at 200?r.p.m. A cell suspension is prepared by washing the cultured cells once with sterile saline.?A. fumigatus?FP1305 is cultured on a potato dextrose agar (PDA) slant for 4 days, and spores are then harvested in sterile saline and collected by filtering through gauze. Antifungal activity against all isolates, with the exception of C. neoformans, is measured by the micro-broth dilution method in 96-well culture plates using RPMI 1640 medium supplemented with?l-glutamine, but without sodium bicarbonate, and buffered to pH 7.0 with 0.165?m?MOPS. ForC. neoformans, yeast nitrogen base-glucose (YNBD) medium is used. For the assay, the test microorganism is inoculated into each well to yield 1×105?CFU/well, and the plates are then incubated for 20?h or 48?h at 37°C. Two end points are determined by microscopic observation: MEC, which is defined as a substantial reduction in fungal growth, and MIC, which is defined as a complete inhibition of growth.
AliasMycamine Sodium, FK463 Sodium, FK 463
Chemical Properties
Molecular Weight1292.26
FormulaC56H70N9NaO23S
Cas No.208538-73-2
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 45 mg/mL (34.82 mM)
H2O: 100 mg/mL (77.38 mM)
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM0.7738 mL3.8692 mL7.7384 mL38.6919 mL
5 mM0.1548 mL0.7738 mL1.5477 mL7.7384 mL
10 mM0.0774 mL0.3869 mL0.7738 mL3.8692 mL
20 mM0.0387 mL0.1935 mL0.3869 mL1.9346 mL
H2O
1mg5mg10mg50mg
50 mM0.0155 mL0.0774 mL0.1548 mL0.7738 mL

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